The Addiction Philosophy Map
Sensitization
Glossaries
| Term | Definition |
|---|---|
| Sensitization |
Sensitization has been defined as the increased response to a drug that follows its repeated presentation but can take on a broader meaning when considered in the context of increased responsiveness of any drug-related phenotype (see below). Psychomotor sensitization, as defined by increased locomotor activation produced by repeated administration of a drug, is more likely to occur with intermittent exposure of drugs, whereas tolerance is more likely to occur with continuous exposure. A conceptualization of the role of psychomotor sensitization in drug dependence has been proposed where a shift in an incentive-salience state described as “wanting” was hypothesized to be progressively increased by repeated exposure to drugs of abuse (Robinson and Berridge 1993).
References Koob, G. 2001. “Drug Addiction, Dysregulation of Reward, and Allostasis.” Neuropsychopharmacology 24 (2): 97–129. doi:10.1016/S0893-133X(00)00195-0.
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